Publication highlights

As of Nov 1st, 2024, we have published a total of more than 45 scientific papers and conference abstracts.

Listed below are some of the more important publications that have come out of the different work packages.

WP1. National Registries:

  • Kessing LV, Ziersen SC, Budtz-Jørgensen E, Gerds T. Response to antidepressants among patients with unipolar depression with and without comorbid epilepsy-a nation-wide population-based longitudinal study. J Affect Disord. 2022 Feb 15;299:1-5. https://doi.org/10.1016/j.jad.2021.11.046
  • Rytgaard HCW, Ekstrøm CT, Kessing LV, Gerds TA. Ranking of average treatment effects with generalized random forests for time-to-event outcomes. Stat Med. 2023 May 10;42(10):1542-1564. https://doi.org/10.1002/sim.9686
  • Bølling-Ladegaard E, Dreier JW, Kessing LV, Budtz-Jørgensen E, Lolk K, Christensen J. Directionality of the Association Between Epilepsy and Depression: A Nationwide Register-Based Cohort Study. Neurology. 2023 Feb 28;100(9):e932-e942. https://doi.org/10.1212/WNL.0000000000201542

WP2. Electronic Patient Data: Text mining and Machine Learning:

  • Garneau N, Hartmann M, Sandholm A, Ruder S, Vulić I, Søgaard A. Analogy Training Multilingual Encoders. Proceedings of the AAAI Conference on Artificial Intelligence. 35, 14 (May 2021), 12884-12892. https://doi.org/10.1609/aaai.v35i14.1752
  • Hjaltelin JX, Currant H, Jørgensen IF, Brunak S. Visualising disease trajectories from population-wide data. Front Bioinform. 2023 Feb 8;3:1112113. https://doi.org/10.3389/fbinf.2023.1112113
  • Vulpius SA, Werge S, Jørgensen IF, Siggaard T, Hernansanz Biel J, Knudsen GM, Brunak S, Pinborg LH. Text mining of electronic health records can validate a register-based diagnosis of epilepsy and subgroup into focal and generalized epilepsy. Epilepsia. 2023 Oct;64(10):2750-2760. https://doi.org/10.1111/epi.17734

WP3. Deep Phenotyping Data from Established Research Cohorts:

  • Sankar A, Ziersen S, Ozenne B, Dam V, Beaman EE, Kessing LV, Fisher PM, Budtz-Jørgensen E, Knudsen GM, Miskowiak KW, Frokjaer VG. Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals. Nature Mental Health. 2024. https://doi.org/10.1038/s44220-024-00299-x
  • Sankar A, Ziersen SC, Ozenne B, Beaman EE, Dam VH, Fisher PM, Knudsen GM, Kessing LV, Frokjaer V, Miskowiak KW. Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders. EClinicalMedicine. 2023 Mar 24;58:101927. https://doi.org/10.1016/j.eclinm.2023.101927

WP4. Deep Phenotyping Data from New Research Cohorts:

  • Marstrand-Joergensen MR, Dam VH, Vinter K, Ip CT, Jensen KR, Jørgensen MB, Hoei-Hansen CE, Ozenne B, Fisher PM, Knudsen GM, Pinborg LH. The BrainDrugs-epilepsy study: A prospective open-label cohort precision medicine study in epilepsy. Neuroscience Applied. 2023;2:101136 https://doi.org/10.1016/j.nsa.2023.101136
  • Jensen KHR, Dam VH, Ganz M, Fisher PM, Ip CT, Sankar A, Marstrand-Joergensen MR, Ozenne B, Osler M, Penninx BWJH, Pinborg LH, Frokjaer VG, Knudsen GM, Jørgensen MB. Deep phenotyping towards precision psychiatry of first-episode depression - the Brain Drugs-Depression cohort. BMC Psychiatry. 2023 Mar 9;23(1):151. https://doi.org/10.1186/s12888-023-04618-x

WP5. Mining neuroimaging data:

  • Beliveau V, Hedeboe E, Fisher PM, Dam VH, Jørgensen MB, Frokjaer VG, Knudsen GM, Ganz M. Generalizability of treatment outcome prediction in major depressive disorder using structural MRI: A NeuroPharm study. Neuroimage Clin. 2022;36:103224. https://doi.org/10.1016/j.nicl.2022.103224
  • Beliveau V, Kaas H, Prener M, Ladefoged CN, Elliot D, Knudsen GM, Pinborg L, Ganz M. Classification of Medical Text in Small and Imbalanced Datasets in a Non-English Language. Proceedings of MIDL 2024. https://openreview.net/forum?id=6ZCChFrGWD